Explorative Sonophotocatalytic Study of C-H Arylation Reaction of Pyrazoles Utilizing a Novel Sonophotoreactor for Green and Sustainable Organic Synthesis

The development of a mild, general, and green method for the C-H arylation pyrazoles with relatively unreactive aryl halides is an ongoing challenge in organic synthesis. We describe herein novel sonophotoreactor based on ultrasonic cleaning bath blue LED light (visible light) that induce copper-catalyzed monoarylation pharmacologically relevant pyrazoles. hybrid effect irradiation discussed to interpret observed synergistic action. A broad array coupled iodobenzene avoids expensive palladium metal or salts, certain designed substrates were attained. Only comparatively inexpensive copper(I)iodide 1,10-phenanthroline used all together as catalyst. presented technique greener way create It significantly reduces amount energy needed.